biomedical devices

FullControl GCode Designer is new open-source and free software for the unconstrained design of additive manufacturing print paths and related aspects of the manufacturing plan.ChallengeThe conventional workflow for additive manufacturing is to develop a CAD model, convert it to triangulated STL surface geometry, slice that model into layers, identify the print path for each layer, and output a manufacturing file (GCode). Each stage introduces errors and limitations.SolutionIn contrast, FullControl GCode Designer (www.fullcontrolgcode.com) turns this whole process on its head. Rather than creating a CAD model and then determining how to move a print head around to simply fill the required 3D volume, FullControl GCode Designer allows the precise print path to be designed directly. This provides unparalleled design freedom and epitomizes the concept of Design for Additive Manufacturing. It allows the designer to think “What can I produce by moving a nozzle with a controlled extrusion rate?” which can allow dramatically different structures to those seen conventionally.<iframe src="https://www.youtube.com/embed/KlxuZ5JnA0k?&amp;wmode=opaque&amp;rel=0" frameborder="0" allowfullscreen="" class="fr-draggable" style="width: 789px; height: 441px;"></iframe>ResultsFullControl allows unlimited exploration of 3D space for printing and of the potential capabilities of 3D printers. It’s been used to print single extrusions 10x wider than the nozzle diameter and other extrusions 10x narrower than the nozzle diameter. That means a 100-fold difference in design resolution of fully dense extrusions is possible from a single system, which is entirely incomparable with conventional additive manufacturing print paths. It’s an example of how FullControl GCode Designer encourages innovative thinking beyond the general design rules, which are actually based on principles of printing with slicer software rather than the true capabilities of 3D printing hardware. Similarly, creating structures with innovative texture and porosity is possible when explicitly designing the 3D movement of the nozzle whilst extruding.<table style="width: 100%;"><tbody><tr><td style="width: 50.0000%;"><div class="fr-img-space-wrap"><img src="https://images.wevolver.com/eyJidWNrZXQiOiJ3ZXZvbHZlci1wcm9qZWN0LWltYWdlcyIsImtleSI6ImZyb2FsYS8xNjIwOTgyNjAwOTc0LVN0cmluZyBleGFtcGxlLnBuZyIsImVkaXRzIjp7InJlc2l6ZSI6eyJ3aWR0aCI6OTUwLCJmaXQiOiJjb3ZlciJ9fX0=" style="width: 300px;" class="fr-fic fr-dib">String Example 10x Narrower&nbsp;</div></td><td style="width: 50.0000%;"><div class="fr-img-space-wrap"><img src="https://images.wevolver.com/eyJidWNrZXQiOiJ3ZXZvbHZlci1wcm9qZWN0LWltYWdlcyIsImtleSI6ImZyb2FsYS8xNjIwOTgyNjIzOTA0LTEweCB3aWR0aCBleGFtcGxlLmpwZyIsImVkaXRzIjp7InJlc2l6ZSI6eyJ3aWR0aCI6OTUwLCJmaXQiOiJjb3ZlciJ9fX0=" style="width: 300px;" class="fr-fic fr-dib" alt="10x Width Example String Structure">10x Width Example String Structure&nbsp;</div></td></tr><tr><td style="width: 50.0000%;"><img src="https://images.wevolver.com/eyJidWNrZXQiOiJ3ZXZvbHZlci1wcm9qZWN0LWltYWdlcyIsImtleSI6ImZyb2FsYS8xNjIwOTgyODE3MjQzLVJhbWVuIGV4YW1wbGUuanBnIiwiZWRpdHMiOnsicmVzaXplIjp7IndpZHRoIjo5NTAsImZpdCI6ImNvdmVyIn19fQ==" style="width: 300px;" class="fr-fic fr-dib">Noodle-Like Structure Example </td><td style="width: 50.0000%;"> <div class="fr-img-space-wrap"><img src="https://images.wevolver.com/eyJidWNrZXQiOiJ3ZXZvbHZlci1wcm9qZWN0LWltYWdlcyIsImtleSI6ImZyb2FsYS8xNjIwOTgyOTQwNTg1LVJpcHBsZSB0ZXh0dXJlIGV4YW1wbGUuanBnIiwiZWRpdHMiOnsicmVzaXplIjp7IndpZHRoIjo5NTAsImZpdCI6ImNvdmVyIn19fQ==" style="width: 300px;" class="fr-fic fr-dib">Ripple-Like Texture&nbsp;</div></td></tr></tbody></table><iframe src="https://www.youtube.com/embed/Sj3Nqtjfw0Q?&amp;wmode=opaque&amp;rel=0" frameborder="0" allowfullscreen="" class="fr-draggable" style="width: 789px; height: 598px;"></iframe>FullControl GCode Designer is applicable for a wide range of designs and applications. It’s been used to print highly controlled simple structures for material characterization as well as complex mathematical forms, in-situ process monitoring, hybrid manufacturing, and production runs &gt;1000. The benefits apply to structures designed and printed at the microscale, such as medical stents, to those at the other end of the spectrum such as large-format polymer and concrete 3D printing. Materials printed with FullControl include thermopolymers, ceramics, silicone, conductive metal inks, biological cell-laden hydrogels, fibre-reinforce polymers and many more materials. Wherever a print path is used, FullControl GCode Designer is relevant because the benefits translate across material systems and size scales. <div class="fr-img-space-wrap"><img src="https://images.wevolver.com/eyJidWNrZXQiOiJ3ZXZvbHZlci1wcm9qZWN0LWltYWdlcyIsImtleSI6ImZyb2FsYS8xNjIwOTgyOTkxNjEwLVN0ZW50IGV4YW1wbGUuanBnIiwiZWRpdHMiOnsicmVzaXplIjp7IndpZHRoIjo5NTAsImZpdCI6ImNvdmVyIn19fQ==" style="width: 300px;" class="fr-fic fr-dib">Stent Example<iframe src="https://www.youtube.com/embed/lWHxT3HQ4Wo?&amp;wmode=opaque&amp;rel=0" frameborder="0" allowfullscreen="" class="fr-draggable" style="width: 789px; height: 465px;"></iframe>&nbsp;</div>Major Benefits of the FullControl GCode Designer are<table border="1" cellpadding="0" cellspacing="0" width="584"></table><ul><li>Quality - the ability to optimize all aspects of the printing procedure to maximize quality, reliability and speed, and overcome any challenges associated with a specific material, printing system or part design.</li><li>Design file&nbsp;efficiency - the design file for the sinusoidal shoe sole concept in the image below requires about 1KB of data, whilst also allowing full parametric adjustment of the size and shape, whereas an STL file (nonparametric) of a similar model may require 1000000 times more data.</li><li>3D print paths and previously impossible structures – the stent in the image above was printed with continuous vertical extrusion (see the video below)</li><li>Hybrid manufacturing and multi-tool processes – FullControl facilitates the use of multiple tools and auxiliary equipment. Explicit design of tool movement paths eliminates the challenges of tool-part collisions during hybrid manufacturing and allows advanced manufacturing activities such as in-situ process monitoring.</li><li>The software is entirely free and requires no installation. It’s integrated into Excel, which is used as an extremely powerful user interface (enabling Excel’s broad functions to be used in design parameters). No CAD software or software licences are required.</li></ul> <div class="fr-img-space-wrap"><img src="https://images.wevolver.com/eyJidWNrZXQiOiJ3ZXZvbHZlci1wcm9qZWN0LWltYWdlcyIsImtleSI6ImZyb2FsYS8xNjIwOTgzMDUxNTQ5LVNob2Vzb2xlLmpwZyIsImVkaXRzIjp7InJlc2l6ZSI6eyJ3aWR0aCI6OTUwLCJmaXQiOiJjb3ZlciJ9fX0=" style="width: 300px;" class="fr-fic fr-dib">Sinusoidal Shoe Sole Example&nbsp;</div><iframe src="https://www.youtube.com/embed/e68Vc69yAo8?&amp;wmode=opaque&amp;rel=0" frameborder="0" allowfullscreen="" class="fr-draggable" style="width: 789px; height: 469px;"></iframe> For a detailed demonstration of the design workflow, see the technical introduction video (20 mins)&nbsp;<iframe src="https://www.youtube.com/embed/yGtyw3oLOVQ?&amp;wmode=opaque&amp;rel=0" frameborder="0" allowfullscreen="" class="fr-draggable" style="width: 791px; height: 437px;"></iframe>More information and other tutorials are available at <a href="//www.fullcontrolgcode.com" rel="noopener noreferrer" target="_blank">www.fullcontrolgcode.com</a><hr>CREATE Education would like to thank Andrew Gleadall for taking the time to share his work in research focusing on biomedical polymers and additive manufacturing at Loughborough University.To learn more about additive manufacturing solutions and how CREATE Education can help and support your University research visit <a href="https://www.createeducation.com/" rel="noopener noreferrer" target="_blank">www.createeeducation.com</a> or speak to our specialists at <a href="mailto:enquries@createeducation.com" rel="noopener noreferrer noopener noreferrer" target="_blank">enquries@createeducation.com</a>.

Ripple texture printed using the a simple print-path design, using a parametric FullControl design file.

Andy Gleadall, Lecturer at Loughborough University develops FullControl GCode Designer in the hope to empower people to do the impossible with scripts and slicers.

Open-Source Software for Unconstrained Design in Additive Manufacturing

This article was discussed in our <a data-saferedirecturl="https://www.google.com/url?q=https://www.wevolver.com/profile/the.next.byte&source=gmail&ust=1640817319915000&usg=AOvVaw2nPRdRwJrXSYYeM9RCFu5x" href="https://www.wevolver.com/profile/the.next.byte" id="isPasted" rel="noopener noreferrer" target="_blank">Next Byte podcast</a>.&nbsp;<iframe height="200px" width="100%" frameborder="no" scrolling="no" seamless="" src="https://player.simplecast.com/816a5019-8dcc-44f6-87cf-e4a0b1f91ce6?dark=false" class="fr-draggable"></iframe>The full article will continue below.<hr><h2>The Elevator Pitch</h2>Neuralink wants to solve brain and spine related illnesses via the seamless integration of a coin-sized device with your brain. In summer 2020, the company held a live product demo hosted by CEO Elon Musk to display what they have been working on.<iframe src="https://www.youtube.com/embed/CLUWDLKAF1M?&amp;t=581s&amp;wmode=opaque&amp;rel=0" frameborder="0" allowfullscreen="" class="fr-draggable" style="width: 788px; height: 438px;"></iframe><h2>The Device</h2>Neural interfacing technology capable of reading and stimulating neuron activity is not necessarily new, but Neuralink's device known as the Link boasts certain features that make it stand out, such as 1024 channels (reportedly 100x more than current competitors), wireless inductive charging, a small form factor (allowing seamless integration with the skull), and utilization of readily available, mass-produced parts making the device as affordable as a new smartphone.&nbsp;<h2><img src="https://images.wevolver.com/eyJidWNrZXQiOiJ3ZXZvbHZlci1wcm9qZWN0LWltYWdlcyIsImtleSI6ImZyb2FsYS8xNjE2ODEyNDgyNDE2LXRoZS1saW5rLnBuZyIsImVkaXRzIjp7InJlc2l6ZSI6eyJ3aWR0aCI6OTUwLCJmaXQiOiJjb3ZlciJ9fX0=" style="width: 788px;" class="fr-fic fr-dib" alt="">Image 1. The Link Device (CNET) The Procedure</h2>A robot will remove a portion of your skull the same size as the device and thread the electrodes to a segment of your brain where small electric charges will stimulate the neurons. &nbsp;Safety and accessibility are some of the primary objectives with this implant.&nbsp;Here is how the team plans on hitting those marks:- Anesthesia is not required- The entire surgery can be done under an hour- Patients can be released from hospital the same day as the procedure- A robot can do the entire procedure to guarantee accuracy- It will automatically inspect and insert electrodes where there are no veins or arteries- It is completely reversible; if you decide you don't want it, take it out without any damages<h2 class="fr-img-space-wrap"><img src="https://images.wevolver.com/eyJidWNrZXQiOiJ3ZXZvbHZlci1wcm9qZWN0LWltYWdlcyIsImtleSI6ImZyb2FsYS8xNjE2ODEyNjM5NDcwLW5ldXJhbGluay1pbnN0YWxsYXRpb24uanBnIiwiZWRpdHMiOnsicmVzaXplIjp7IndpZHRoIjo5NTAsImZpdCI6ImNvdmVyIn19fQ==" style="width: 788px;" class="fr-fic fr-dib">Image 2. Link procedure process (CNET) The Motivation</h2>A key driving force behind this project is providing an inexpensive, safe, convenient, and reversible neural interfacing solution that could potentially eliminate neural illnesses while offering those suffering from spinal injuries the chance to regain their mobility. Still, that's not the most ambitious part of this project.Musk has repeatedly expressed his concern about the rapid rise of artificial intelligence (AI) and what it could mean for the future of humanity; therefore, he sees the Link as a viable life raft where the human mind could integrate with AI. In fact, the Neuralink team already demonstrated an elementary version of this long-term goal by having a monkey control a computer using their device to play video games.<h2>The Functionality</h2>Usually at this point everyone has the same big question: does it work? Well, the proof is in the pigs.The stars of the 2020 product demo were three little pigs that helped demonstrate the safety of the Link. The first pig had never had an implant, the second had an implant at some point but it had been removed, and the third was the one currently with an implant; the major takeaway was that you will not experience any noticeable negative changes to your behavior with or without the implant (even if you've removed it).Gertrude, the third pig, was proudly showing off her implant to the audience by having the neuron impulses connected to her snout visualized while being fed. Every time her snout touched food, the audience saw a spike.More impressively, the demo contained a video of a pig on a treadmill whose joint movements were being almost perfectly predicted using the information from the implant. This could theoretically help those with spinal injuries by relaying the movement information that they are thinking to a secondary implant located at the base of the spinal cord thereby enabling movement.&nbsp;<div class="fr-img-space-wrap"><div class="fr-img-space-wrap"><img src="https://images.wevolver.com/eyJidWNrZXQiOiJ3ZXZvbHZlci1wcm9qZWN0LWltYWdlcyIsImtleSI6ImZyb2FsYS8xNjE2ODEyODIwMzg5LVBpZyB3YWxrLnBuZyIsImVkaXRzIjp7InJlc2l6ZSI6eyJ3aWR0aCI6OTUwLCJmaXQiOiJjb3ZlciJ9fX0=" style="width: 788px;" class="fr-fic fr-dib">Image 3. Predicted vs. actual joint movements (CNET)&nbsp;During the Q&amp;A, Elon mentioned that it is possible to have a feature for the Link where the user will be able to upload their memories to the cloud and replay them at will.&nbsp;</div></div><h2>The When</h2>Neuralink received a breakthrough designation from the FDA in July 2020 and it looks like they are on track to start human trials by the end of 2021.&nbsp;

Neuralink is an ambitious startup backed by Elon Musk that hopes to rid the world of brain-related illnesses using a coin-sized chip

Neuralink: The Company That Wants To Put A Chip In Your Head

"I think a hero is an ordinary individual who finds strength to persevere and endure in spite of overwhelming obstacles."These are Christopher Reeve's words. The iconic actor portrayed Superman in the 1978 blockbuster and its three later sequels. Reeve himself had to endure such obstacles towards the end of his life after becoming paralyzed from the shoulders down following a horse-riding accident.Today, as life imitates art, a combination of adversity and technology creates the next generation superheroes. Like Limbitless Solutions, a non-profit organization spun-off from the University of Central Florida. The team of now former students is developing technology that empowers children with limb differences.Amongst a range of accessibility solutions, the company creates personalized 3D printed prosthetic 'bionic' arms. Customized to resemble popular superhero bodysuits from movies and video games, the prosthetic dramatically improve the wearer's life quality.<h2>Advanced electronics</h2>To make the limb work, non-invasive electromyographic (EMG) sensors pick up signals generated by muscle movements in the child's arm. The sensors are stickers placed on the upper arm above muscle groups that move when flexed. When an EMG signal is detected, the bionic arm actuates. Below this is a socket to hold the prosthetic in place, matched to the individual child, and it fits regardless of whether or not the elbow is present. The forearm section of the bionic arm contains a battery pack that powers the motors controlling the multi-gesture movements.The hand unit contains the core electronics and motors for the fine control of the individual fingers. This unit includes an Insight SiP ISP1507-AX RF module based on Nordic Semiconductor's nRF52832 SoC. It enables the bionic limb to be set-up, adjusted, and monitored wirelessly via an iOS or Android partner app. For example, by configuring the app, you can determine the degree of muscle-flexing required to generate a particular force in the fingers. The app also provides easy access to status information such as the battery level.<h2>Practice makes perfect</h2>Learning to use a new arm takes practice; determining the various thresholds of muscle strength, for example, is difficult. So to make it fun and engaging, Limbitless Solutions has gamified the process. The Nordic-powered Insight SiP module acts as the Bluetooth LE wireless controller for a computer- or tablet-based game. The games take a classic level-based approach, starting with simple gestures such as opening and closing the hand and then unlocking additional, more complex manipulations as each level is completed.In addition to the looking part, the prosthetic arm must be comfortable, lightweight, and easy to use. The miniaturized eight by eight by 1 mm module is suitable for this purpose as it is for any other space-constrained application. Meanwhile, the Bluetooth LE connectivity allows parents to easily calibrate and adjust the arm from their smartphone, using a wireless technology they readily understand.<h2>Affordable technology</h2>Cosmetically realistic myoelectric hands that open and close can cost $20,000 to $30,000 or even more, while a neuroprosthetic arm may cost as much as $100,000. By combining cost-effective 3D printing with affordable electronics and wireless technology, the company believes it can reduce production cost to as little as $5000 per bionic arm. Essential if the technology is to become widespread as children outgrow prosthetics quickly.As a natural next step, the company has expanded its vision to support adults with limb differences—particularly veterans and first responders—of which there are unfortunately many in the United States. According to the Amputee Coalition, nearly two million people live with limb loss in the U.S. Approximately 185,000 amputations take place each year, a number expected to double by 2050.<h2>Project expansion</h2>Through the process of a clinical trial, Limbitless Solutions has so far gifted 40 bionic arms to 36 children and teenagers. By expanding its R&amp;D and manufacturing capabilities soon, the company hopes to increase to 100 through gifts and donations. If successful, the project could give families and children hope worldwide and create thousands of more superheroes in the process.<hr>This article was first published on Nordic's&nbsp;<a href="https://blog.nordicsemi.com/getconnected" rel="nofollow" target="_blank"></a><a href="https://blog.nordicsemi.com/getconnected?utm_campaign=2021%20wevolver" rel="nofollow" target="_blank">Get Connected Blog</a>.

By combining cost-effective 3D printing with affordable electronics and wireless technology, new accessibility solutions empower children with limb differences.

Smart limbs make heroes by design

Israeli researchers create the first 3D printed heart. Source: Israel 21

In the near future, 3D bioprinting will allow medical professionals to engineer and 3D print patient-specific organs for organ transplants in a few hours.

3D Bioprinting Gives Researchers the Power To Create Artificial Organs

With the reusable workflows in nTop Platform and FDM 3D printing, industrial designers are able to rapidly iterate and prototype the design of functional parts. This blog highlights a use case for animal prosthetics and points to how this can be done in other cases such as designing a foot for an amputee so they can rock climb.Industrial design is an incredible discipline combining the perspectives of art, engineering, business, and even science all in one. It is these perspectives that any product requires to be successful. If a product does not look good, it will not sell. If the product doesn’t function well, it will not sell. If a product does not solve a specific problem at the right cost, it will not sell. It is the role of the industrial designer to balance these elements in the conceptualization and execution of a new product, for the purpose of developing a product that meets the requirements beyond just the needs of a user.&nbsp;At <a href="https://www.divedesignco.com/" rel="noopener" target="_blank">DiveDesign</a>, we develop products with the holistic approach of an industrial designer at the forefront, with an emphasis on leveraging the latest in technologies to bring our clients even further, faster. It’s this methodology that reshapes industries as so much must be taken into account to change perceptions and enable change.&nbsp;In our constant pursuit of the latest and greatest, we’ve begun incorporating nTopology into our workflows. Especially for the purpose of designing end-use 3D printed parts for applications that do not require mass manufacturing, but smaller-scale production that was previously inaccessible to most. With the rise of additive manufacturing, low run production of highly useable parts at an affordable cost is finally possible. There is a huge window of opportunity for parts that could not be made previously as minimum order quantities required for production were simply too high, or the parts were too complex for conventional processes. Our work with <a href="https://bionicpets.org/" rel="noopener" target="_blank">Bionic Pets</a> is a great example of this.&nbsp;Bionic Pets is a leader in custom animal prosthetics for animals of all kinds, especially dogs. Their founder Derrick Campana has worked on animals ranging from elephants to birds and everything in-between. However, everything they make is done entirely by hand through Derrick’s incredibly skilled craftsmanship. While this works very well in most cases, prosthetics like the full limb replacement for dogs he offers takes up to 15 hours to fabricate. This type of prostheses is incredibly challenging and time-consuming to make by hand, but in high demand as thousands of dogs have a front limb removed every year due to trauma or cancer. Without a prosthesis, the remaining front limb deteriorates much faster due to the unnatural weight distribution and increased strain. In many cases, when a dog loses mobility due to the deterioration of the remaining limb, the dog is sadly put down.Due to how labor-intensive this design was to make, Derrick had to turn down many requests. So, we stepped in to help. We were able to re-evaluate the process of constructing them, incorporating 3D scanning, 3D design algorithms, and 3D printing. The perfect candidate for low volume 3D printed production to take the weight off of Derrick.&nbsp;<img src="https://images.wevolver.com/eyJidWNrZXQiOiJ3ZXZvbHZlci1wcm9qZWN0LWltYWdlcyIsImtleSI6ImZyb2FsYS8xNjA2Mzc5MjAzNDE3LUREMi5wbmciLCJlZGl0cyI6eyJyZXNpemUiOnsid2lkdGgiOjk1MCwiZml0IjoiY292ZXIifX19">Old front limb prosthetic compared&nbsp;to the new design&nbsp;With the new printed vest design, the product can be made in a fraction of the time and maintains strength and durability thanks to the amazing properties of TPU. However, we began to find challenges with the feet, still made the old fashioned way with heat bent plastic and rubber. Not only did they take skill, patience, and too much time to fabricate, we began getting complaints that they were breaking or deforming. With orders piling up and complaints streaming in, we needed a new solution, and fast.&nbsp;Thanks to another project we worked on that will be discussed in the full video, we had used nTopology to build prosthetic feet for a rock-climbing amputee. We were able to take the learnings from the various material and lattice tests we conducted, and quickly generate prosthetic feet concepts for the dogs utilizing the same toolkits and workflows. In addition to this, we were introduced to a type of TPE we had never used, called TPC. Very similar to what we were using for the vest, however, with far better energy return.<img src="https://images.wevolver.com/eyJidWNrZXQiOiJ3ZXZvbHZlci1wcm9qZWN0LWltYWdlcyIsImtleSI6ImZyb2FsYS8xNjA2Mzc5MjMyNzczLUREMy03Njh4NDI5LnBuZyIsImVkaXRzIjp7InJlc2l6ZSI6eyJ3aWR0aCI6OTUwLCJmaXQiOiJjb3ZlciJ9fX0=">Iterations of prosthetic feet in nTop Platform&nbsp;With the speed and versatility of FDM 3D printing, and the iterative power and ability to easily reuse workflows in nTop Platform, we were able to rapidly design, test, and ship a new solution in only days that previously would have taken weeks if not months had we taken a route requiring conventional molding. We seamlessly shipped out the replacements and installed the new design on all new prosthetics, without one hiccup. Best of all, the product will continue to evolve as we gain more feedback. We will soon be able to tailor the foot design to the specific needs of each dog, just as the vests are.&nbsp;<img src="https://images.wevolver.com/eyJidWNrZXQiOiJ3ZXZvbHZlci1wcm9qZWN0LWltYWdlcyIsImtleSI6ImZyb2FsYS8xNjA2Mzc5MjU0NDMyLURENC5wbmciLCJlZGl0cyI6eyJyZXNpemUiOnsid2lkdGgiOjk1MCwiZml0IjoiY292ZXIifX19">Furry friends modeling the new vest and foot design&nbsp;We cannot wait to see how more industrials designers utilize nTop Platform with additive manufacturing to reimagine the many products we interact with every day or the products that live beneath the surface that make the day to day possible.&nbsp;<hr>This article was first published on the&nbsp;<a href="https://ntopology.com/blog/2020/11/12/3d-printed-prosthetics-for-animals/" rel="noopener noreferrer" target="_blank">nTopology blog</a>.

Derrick of Bionic Pets modeling a front limb prosthetic

With the reusable workflows in nTop Platform and FDM 3D printing, industrial designers are able to rapidly iterate and prototype the design of functional parts.

Developing 3D printed Prosthetics for Pets with nTop Platform

This is the first article in a series dedicated to integrated photonics. In this article, we introduce you to the technology, its history, and its materiality.&nbsp;<h2>What is integrated photonics?</h2>Integrated Photonics (IP) is the use of light for applications traditionally tackled by electronics. It can be used in a wide range of areas including telecommunications such as 5G networks, biosensors for speeding up medical diagnosis, and in automotive where it is used in LiDAR. IP consists of integrating multiple photonic functions on a Photonic Integrated Circuit (PIC) fabricated using automated wafer-scale generic integration technology over silicon, silica, or Indium Phosphide (InP) substrates. Integrated photonics dramatically improves the performance and reliability of these photonic functions while simultaneously reducing the size, weight, and power consumption.<h2>Electronics versus Photonics</h2>A good introduction to IP is by understanding its similarities and differences with traditional electronic circuits. Where electronics deal with the control of electrons on a chip, photonics does the same with photons. Photons are the fundamental particles of light.Conventional integrated circuits (ICs) conduct electricity by allowing the flow of electrons through the circuit. Electrons are negatively charged subatomic particles that interact with both other electrons and other particles. These interactions slow electrons down as they move through circuits, this limits the amount of information that can be transmitted; it also generates heat, which in turn causes energy and information losses.Photonic integrated circuits (PICs) use photons. Photons move at the speed of light with almost no interference from other photons. This greatly increases the bandwidth (the data transfer rate) and speed of the circuit, without big energy losses making PICs significantly more efficient than their IC counterparts.&nbsp;Integrated photonic components use "waveguides", which confine and direct the light in the desired directions (by total internal reflection), much the same way as metallic wires do for electrical signals. A PIC provides functions for information signals on optical wavelengths typically in the <a href="https://en.wikipedia.org/wiki/Light#:~:text=Visible%20light%20is%20usually%20defined,%E2%80%93750%20terahertz%20(THz)." target="_blank">visible spectrum</a> or near-infrared 850 nm-1650 nm.The elements on a PIC are connected via waveguides. The chip elements can be both passive (e.g. couplers, switches, modulators, multiplexers) and active (e,g amplifiers, detectors, and lasers). These components are integrated and fabricated onto a single substrate, which creates the compact and robust photonic device.A key difference between electronic circuits and PICs is in the primary device that is used for fabrication. In an electronic integrated circuit, the main device is the transistor. But, in PIC, there is no particular main device that dominates in the fabrication. According to its application, the PIC will be designed with a range of fabrication devices. This integration presents opportunities to reduce current bulky, complex, and expensive optical systems in an integrated chip-scale way that has increased stability and robust operation, reduced size and power consumption, and cost-effective large-scale fabrication of even complex circuits.<img class="fr-fic fr-dib" src="https://images.wevolver.com/eyJidWNrZXQiOiAid2V2b2x2ZXItcHJvamVjdC1pbWFnZXMiLCAia2V5IjogImZyb2FsYS8xNjA1MTAzODE2MTczLXRpbWVsaW5lNS0wMS5qcGciLCAiZWRpdHMiOiB7InJlc2l6ZSI6IHsid2lkdGgiOiA5NTAsICJmaXQiOiAiY292ZXIifX19" style="width: 788px;"><h1>Fabrication and materials</h1>PICs are currently fabricated on both standard element semiconductors and compound semiconductors to dielectric materials and <a href="https://www.rp-photonics.com/nonlinear_crystal_materials.html" target="_blank">nonlinear crystal materials.</a> The specific application requirements drive the choice of the most suitable substrate material as each material has its own specific advantageous features and limitations. For example, lithium niobate can be used to fabricate low-loss waveguide devices or integrated flexible chalcogenide glass to make photonic crystals with mechanical flexibility.The transparency and <a href="https://en.wikipedia.org/wiki/Refractive_index" target="_blank">refractive index</a> of the materials as well as their ability to directly generate light defines the properties of the finished PIC and its uses. The material's bend loss and bend radius also impact the PIC properties. Bend loss describes propagation losses (reduction in power density) in an optical fiber (or other waveguide) caused by bending while the bend radius describes the amount a fiber can bend without breaking. The major substrates today are Indium Phosphide (InP)-based monolithic integration and Silicon Photonics but Silica (SiO2 &nbsp;and Silicon Nitride (SiN) are also growing areas.<h2>Indium Phosphide (InP)</h2>Indium phosphide (InP) is the most developed platform for PICs. InP allows for the integration of both active and passive elements such as high-performance amplifiers, lasers, modulators, and detectors in combination with interferometers within one chip in the 1.1 – 1.6 μm spectral window. InP integrated photonics are used in data communications, precision metrology (for example LIDAR in autonomous vehicles), spectrometry, and imaging. Much of the most impactful research into InP has been done in the Netherlands and several organizations and research groups continue to lead the way. The Smart Photonics foundry in Eindhoven is a leader in production services for Indium Phosphide based photonic components. The foundry and its associated services offer support for researchers and businesses to test and expand their use of InP PICs.<h2>Silicon Photonics (SiPh)</h2>Building on the success of silicon (Si) as the foundation of IC reliability, silicon photonics (SiPh) is a critical part of integrated photonics development. Silicon photonic devices can be manufactured using existing semiconductor fabrication techniques, and as silicon is already used as the substrate for most ICs, both optical and electronic components can be integrated on to the chip to create hybrid devices.Si is <a href="https://en.wikipedia.org/wiki/Transparency_(optics)" target="_blank">transparent</a> to <a href="https://en.wikipedia.org/wiki/Infrared_light" target="_blank">infrared light</a> with wavelengths above about 1.1 micrometers (μm) &nbsp;- making it suitable for <a href="https://en.wikipedia.org/wiki/Fiber_optic_telecommunication" target="_blank">fiber optic telecommunication</a> systems which uses 1.55 micrometer <a href="https://en.wikipedia.org/wiki/Wavelength" target="_blank">wavelength</a>. It also has a very high <a href="https://en.wikipedia.org/wiki/Refractive_index" target="_blank">refractive index</a>, of about 3.5, much higher than that of silicon oxide (1.5), which allows strong confinement of light in Si structures embedded in silicon oxide (waveguides). These properties make Si well suited for usage in telecom.<img src="https://images.wevolver.com/eyJidWNrZXQiOiAid2V2b2x2ZXItcHJvamVjdC1pbWFnZXMiLCAia2V5IjogImZyb2FsYS8xNjA1MTAzODQyNjM0LUdJSlMxMjI4LUVkaXQuanBnWzc3XS5qcGciLCAiZWRpdHMiOiB7InJlc2l6ZSI6IHsid2lkdGgiOiA5NTAsICJmaXQiOiAiY292ZXIifX19">PHIX – Gijs van Ouwerkerk, courtesy of QuiX&nbsp;<h2>Silicon Nitride (SiN)</h2>Silicon Nitride (SiN) based platforms are of recent growing interest due to their large transparency window (from visible to MIR) and ultra-low optical losses compared to other PIC platforms. Silicon nitride (SiN) excels at passive light processing in the visible, near-infrared (NIR), and IR range thanks to its very low light intensity loss in the waveguide, small bend radii, and adjustable polarization. If required by the application, active components made in another technology platform (i.e. InP) can be coupled to SiN PICs into the same package through PIC-level hybrid integration processes.The proprietary waveguide concept, called TriPleX, from the Dutch company, <a href="https://www.lionix-international.com/" rel="noopener noreferrer" target="_blank"></a><a href="https://www.lionix-international.com/" rel="noopener noreferrer" target="_blank">Lionix International</a>, has the lowest propagation losses reported for silicon nitride waveguides (0.1 dB/cm down to 0.1 dB/m). It operates in a broad wavelength band ranging from 405 nm to 2350 nm. Furthermore, they have developed a patented tapering method that converts low contrast modes for optimal fiber coupling, to high contrast modes for small bending radii.&nbsp;There are several large scale <a href="https://www.nwo.nl/en/research-and-results/research-projects/i/21/32421.html" target="_blank">research projects</a>  underway that are aiming to eliminate the number of current assembly steps and provide both lossless transitions between materials and a lower-cost manufacturable process.<h2>Lithium niobate (LiNbO3)</h2>Lithium niobate (LiNbO3) is a nonlinear crystal material suitable for devices performing nonlinear functions - that is functions that take advantage of this material property. A good example <a href="https://en.wikipedia.org/wiki/Electro-optic_modulator" target="_blank">electro-optic modulators</a> or acousto-optic transducers. Waveguides can be fabricated on lithium niobate substrates controlled by a lithographic method. Adding or ‘doping’ rare-earth ions to Lithium niobate makes amplifiers and lasers possible. &nbsp;LiNbO3 has the property of birefringence - which means its refractive index depends on its polarization direction. This creates opportunities for polarization control, which may then be used for filtering purposes or other similar applications. However, this property also makes it more difficult to form polarization-independent devices, which are often required for optical fiber communications.<h1>Innovation through collaboration</h1><a href="https://www.photondelta.com/" rel="noopener noreferrer" target="_blank">PhotonDelta</a>, a Dutch public-private partnership consisting of a cohesive cluster of companies and highly qualified knowledge institutes, has been formed to accelerate and reduce time to market of integrated photonics products. PhotonDelta stimulates and facilitates cooperation between stakeholders within the ecosystem providing fertile ground for developing the common business strategy, setting goals, and stimulating cooperation between partners in the Netherlands and beyond. PhotonDelta helps to amplify and scale existing companies and kickstart new ones by having access to significant funding through its industry building and growth accelerator program.<h1>Conclusion</h1>Integrated Photonics is an emerging field of technology already demonstrating massive future potential in applications across multiple fields. Much of this emerging industry developments/scale-ups and relevant R&amp;D are occurring in the Netherlands supported and driven by the leadership of PhotonDelta. PICs will continue to increase in efficiency and speed, both driving disruptive innovation, I.e. enabling (radically) new products and markers, as well as improving existing systems.In our next article, we explore the key technology areas for Integrated Photonics. We’ll guide you through how the technology is impacting automotive, biosensors, communications, quantum computing, and data storage.<div align="center"><hr align="center" size="0" width="100%"></div><h1>About the sponsor: PhotonDelta</h1>PhotonDelta is a growth accelerator for the Dutch integrated photonics industry. Its objective is to promote the adoption of integrated photonics and support companies to get prioritized access to the Dutch Integrated Photonics supply chain. Furthermore, PhotonDelta runs a new business creation program that provides companies, ranging from startups to SMEs and big organizations, with access to strategy, market, and funds.Through its wide network within the industry, PhotonDelta has gathered insights on market trends, challenges, and product roadmaps. This information is used to drive business creation, investments, and strategic technology roadmaps. Furthermore, PhotonDelta actively supports start-ups and SMEs to facilitate their involvement with the Dutch integrated photonic supply chain. This includes facilitating options for establishing a solid presence in the Netherlands.<img class="fr-fic fr-dib" src="https://images.wevolver.com/eyJidWNrZXQiOiJ3ZXZvbHZlci1wcm9qZWN0LWltYWdlcyIsImtleSI6ImZyb2FsYS8xNjA1NjEzNjc0MjkwLXBob3RvbiBkZWx0YSBhcnRpY2xlIGJvdHRvbSBiYW5uZXIuanBnIiwiZWRpdHMiOnsicmVzaXplIjp7IndpZHRoIjo5NTAsImZpdCI6ImNvdmVyIn19fQ==" style="width: 788px;"> <div language="JavaScript"><div language="JavaScript"><div language="JavaScript"><div language="JavaScript"> </div></div></div></div>

 PHIX – Gijs van Ouwerkerk, courtesy of QuiX

Article 1 of our Integrated Photonic Series: Integrated Photonics is set to revolutionize electronic devices, circuits, and telecommunication systems

An introduction to Integrated Photonics

This article is sponsored by PhotonDelta, a growth accelerator for the integrated photonics industry. Its network consists out of chip designers, module companies, foundries, researchers, software developers as well end-customers. Through their sponsorship, PhotonDelta supports knowledge building and resource sharing on this topic.<h2 data-element-id="headingsMap-4-0">Introduction</h2>Integrated photonics is the rapidly emerging field of photonics that works to integrate multiple photonic functions into integrated circuits for communication, sensing, and, going forward, computing applications. Complex photonic circuits can now generate, process, and detect light, in analogy to how electronic integrated circuits do for electronic signals by way of connecting multiple discrete single-function components (e.g. dedicated lasers, photodetectors) and relevant optical interfaces.As many communication and sensing applications already make use of light, solid-state integration on a Photonic Integrated Circuit (PIC) carries the promise of significant reduction of size, weight, manufacturing costs, and power consumption while improving reliability, in comparison to the assembling and packaging of multiple discrete photonics components and bulk optics.Integrated photonics are already applied in impactful applications such as high-speed fiber-based optical communications, next-generation low-cost environmental mapping systems, and lab-on-chip biosensors for fast and accurate analysis of biological samples.For a more comprehensive introduction to Integrated Photonics read our previous <a href="https://www.wevolver.com/article/an-introduction-to-integrated-photonics" rel="noopener noreferrer" target="_blank" id="isPasted">foundation article on the topic</a>. This article will focus on the areas PICs are being applied and how they are accelerating innovation in these sectors.<h3 data-element-id="headingsMap-5-0">Automotive</h3>The automotive industry is going through a rapid transformation driven by trends including electrification, autonomous vehicles &amp; driver support systems, and changes in mobility patterns and city infrastructure. These trends will influence not only the physical design and capability of commercial, public, and individual vehicles but also the broader social and economic impacts of changes to car/fleet ownership and use. The increased need for sensors in vehicles, in the electric/hybrid drivetrains as well as in advanced driver-assistance systems (ADAS) up to autonomous driving systems, creates new significant opportunities for the integrated photonics industry (Figure 1).<h3 data-element-id="headingsMap-6-0"><img src="https://images.wevolver.com/eyJidWNrZXQiOiAid2V2b2x2ZXItcHJvamVjdC1pbWFnZXMiLCAia2V5IjogImZyb2FsYS8xNjA2MjAzOTEyMTU5LUFEQVMuanBnIiwgImVkaXRzIjogeyJyZXNpemUiOiB7IndpZHRoIjogOTUwLCAiZml0IjogImNvdmVyIn19fQ==">Figure 1. An example of an ADAS system.&nbsp;Lidar</h3>The role of integrated photonics in the automotive sector has so far been modest, but its potential is extensive and touches all aspects of the vehicle and system design. One promising area is in Lidar (BAD) (Light Detection And Ranging) systems, used to assist autonomous vehicles to ‘see’. Currently, these laser-based systems are extremely expensive, often costing more than tens of thousands of dollars for a single system which limits their commercial availability. Additionally, these early systems carried with them concerns about their reliability, eye safety (due to the close to visible range wavelength regions used), and limited accuracy (given the relatively simple ranging schemes possible). Integrated photonics offers the opportunity to reduce this cost and increase system safety[1].<a href="https://news.mit.edu/2010/explained-doppler-0803#:~:text=The%20Doppler%20effect%2C%20or%20Doppler,the%20source%20approaches%20the%20observer." rel="noopener noreferrer" target="_blank" id="isPasted">The Doppler effect</a> is the term given to the phenomena of the frequency of a wave changing when its source is in motion relative to an observer. Frequency-modulated continuous-wave (FMCW) Lidar works by measuring the doppler shift coherently, preventing interference from sunlight and other lidar systems. This system design offers distance resolution but comes at the cost of low acquisition speed and requires a highly coherent, as well as precisely chirped, laser source. Researchers from the Swiss Federal Institute of Technology have <a href="https://www.nature.com/articles/s41586-020-2239-3.epdf?sharing_token=8awhPK7bY8-NhCsu_UpQ4tRgN0jAjWel9jnR3ZoTv0O5vYNz8blttgNr8QtgeZcckxVk2YwyJUrdECE9S2yFSZiDVQhFdep4yLgcTlf3Xpzj-Vh0QRmBjODOGv3VU9UN1FbfxVj2R7kdYd-x8K4xH3pscwq9ozftp_lxb0GWasRGEb14fDj258OnxyFYLYzOY9V6eWP8XstlG_lFYEbROutXTZHPaKpADZtTFsUBI-A%3D&tracking_referrer=physicsworld.com" target="_blank" id="isPasted">outlined</a> how a novel approach multiplexes a single FMCW laser using a high-quality silicon-nitride microresonator on a photonic chip.PhotonDelta is currently developing a roadmap for integrated photonics applications for the automotive industry, with a focus on the potential of Lidar, set to be published in early 2021.&nbsp;<h3 data-element-id="headingsMap-7-0">Continuum-of-Care</h3>The traditional healthcare paradigm of focusing on diagnosis and treatment of patients only after they are seriously ill has been under growing pressure to change due to increasing costs, growing populations, and rapid demographic changes (i.e. aging). There is a growing <a href="https://www.mckinsey.com/industries/healthcare-systems-and-services/our-insights/seven-healthcare-industry-trends-to-watch-in-2020" rel="noopener noreferrer" target="_blank" id="isPasted">global trend&nbsp;</a> to approach healthcare more holistically, with a particular focus on prioritizing prevention before illness, ensuring that populations can stay healthy for as long as possible. Additionally, there is also an increased focus on rehabilitation, ensuring that former patients can rapidly and fully recover to good health using a broader approach to healthcare than just medication.Traditionally the diagnosis and treatment of patients occur in specialized centers (i.e. clinics and hospitals). A holistic approach to health requires decentralization, i.e. shifting diagnosis and treatment closer to the patients (BAD), with the ultimate vision including remote diagnosis and treatment from people’s homes. Despite strong evidence that this approach would reduce national health costs and improve patients' prognosis while reducing hospital time and resources, there has been little movement in the national health care approach around the world. To implement a more forward-looking healthcare method, an alternative to hospital-specific medical devices must be created – and this is where Integrated Photonics can provide the answer.Light has the relevant property that a number of its parameters may change under the effect of its interaction (e.g. reflection, refraction, scattering) with bio body tissues and fluids. Light-based sensors have already been adopted into many medical devices and they will continue to be introduced at a large scale.Integrated Photonics offers the possibility to dramatically reduce the cost and size of hospital oriented medical devices and therefore kickstart a new approach to diagnosis and treatment. Several global companies are addressing this challenge by developing Integrated Photonic technology in two main areas: &nbsp;bio-sensing (see below) and Optical Coherent Tomography (OCT) &nbsp;which is a diagnostic method for eyes, skin, and neurology diseases. Within this emerging area, PhotonDelta is developing a roadmap for integrated photonics applications for the Continuum-of-Care, with a focus on bio-sensing, set to be published in early 2021.<h3 data-element-id="headingsMap-8-0">Biosensors</h3>Silicon Nitride PICS (SiN PICs) are optimal for the detection of biological molecules. They work in a very wide wavelength range from visible to near-infrared which means they avoid the water absorption window of water and allow fluorescence detection. This wavelength range makes it easy to combine them with a cheap laser source. SiN allows for a small bend radius which means the light-contacting waveguide can be rolled up to create a very long light path on the chip’s surface. This results in a long interaction time of the light with biomolecules that are in the vicinity of the surface making the biosensors based on SiN PICs highly sensitive. They also offer the ability for simultaneous multiplexed sensing of different target molecules by using the same body fluid (e.g. blood, saliva) – ie they can test for multiple items at once. &nbsp;A full view of how a photonic biosensor works can be accessed here. (BAD)<img src="https://images.wevolver.com/eyJidWNrZXQiOiAid2V2b2x2ZXItcHJvamVjdC1pbWFnZXMiLCAia2V5IjogImZyb2FsYS8xNjA2MjA1MTIyOTU0LVNvbGVyLWltZzEuanBnIiwgImVkaXRzIjogeyJyZXNpemUiOiB7IndpZHRoIjogOTUwLCAiZml0IjogImNvdmVyIn19fQ==">Nanophotonic interferometric biosensor for multiplexed analysis of protein and nucleic acid biomarkers. [Dámaso Torres/ICN2]&nbsp;PIC-based biosensors are expected to be applied in a multitude of areas, such as health-related targets (e.g. glucose monitoring in diabetes patients, early detection of the onset of cancer or infectious diseases), environmental applications (e.g. the detection of <a href="https://en.wikipedia.org/wiki/Pesticides" target="_blank" id="isPasted">pesticides&nbsp;</a>and pollutants), and the food industry (e.g. determination of antibiotics or hormon <a href="https://en.wikipedia.org/w/index.php?title=Drug_residue&action=edit&redlink=1" target="_blank" id="isPasted">residues</a> in food, early detection of infectious diseases). Dutch-based Lionix International is developing PIC-based biosensors to develop rapid testing (BAD) for COVID-19.<h2 data-element-id="headingsMap-9-0">Data &amp; telecommunications</h2>Research indicates that the total internet demand is growing at about 40% per year. This is driven by a huge appetite for video - Netflix now takes up to 30% of the internet’s bandwidth at peak hours. Mobile access to video is becoming more widespread as are video-centred applications such as Tik-Tok. Data consumption per device is rapidly increasing. Mobile users in North America are expected to reach 48 GigaBytes (GB) per month per smartphone by the end of 2023[2]. Integrated photonics has the potential to provide significant power, space, and cost savings, and new functionality when integrated into optical communication systems. They can also increase the transmission capacity (BAD) of existing communication systems.Dutch-based startup, <a href="https://effectphotonics.com/" rel="noopener noreferrer" target="_blank" id="isPasted">Effect Photonics&nbsp;</a>, has been developing in this field for more than a decade and their first product a 10 Gb/s DWDM tuneable optical transceiver module is now ready for market (Figure 2). The module has an autotuning feature, in which the module scans the network for what channel to use. No engineer is required to program it at installation: it’s plug-and-play and hot-pluggable. The next step is higher bandwidths, a 25Gb/s is in the works with 100 and 400/600 channels in the works too.<img src="https://images.wevolver.com/eyJidWNrZXQiOiAid2V2b2x2ZXItcHJvamVjdC1pbWFnZXMiLCAia2V5IjogImZyb2FsYS8xNjA2MjA0Mjc3MzY4LUVmZmVjdC1QaG90b25pY3MtVUstOTQtd2ViLXJlYWR5LmpwZyIsICJlZGl0cyI6IHsicmVzaXplIjogeyJ3aWR0aCI6IDk1MCwgImZpdCI6ICJjb3ZlciJ9fX0=">Figure 2: A tuneable optical transceiver module.<h2 data-element-id="headingsMap-10-0">Advanced components for 6G networks</h2>Photonic technology will play a key role in 6G networks across different segments. In 6G transport, it has the potential to allow the transmission and routing of large amounts of data traffic at an acceptable cost. In data centers, photonic interconnect and switching will introduce a new architecture that can reduce energy consumption while providing a high level of flexibility in resource utilization. There is also promising research into photonic <a href="https://www.osapublishing.org/abstract.cfm?uri=OEDI-2018-OT3A.2" target="_blank" id="isPasted">beam-forming networks&nbsp;</a> based on packaged integrated photonic circuits. Additionally, integrated photonics may be able to help achieve some functions of future radio systems that will enable further evolution towards the 6th generation of mobile networks.<h3 data-element-id="headingsMap-11-0">Quantum Computing</h3>Quantum computers based on photons instead of electrons have many advantages. A key advantage is the ability for the computer to operate at room temperature A classic quantum computer needs to be maintained at temperatures well below freezing for optimal performance making their storage and maintenance extremely costly and fragile.Earlier this year Canadian based startup, Xanadu announced the release of the world's first publicly available photonic quantum computing platform. Applicants can access 8, 12, and soon 24 qubit machines over the cloud. Despite this historic breakthrough, the potential of photonic quantum computing has not even begun to be tapped.<h3 data-element-id="headingsMap-12-0">More applications to come</h3>Other application domains and market segments for Integrated Photonics are expected to mature within 5-10 years. These include fiber-based sensor systems for real-time, and highly accurate distributed structural health monitoring, applications in energy grids and wind turbines, defense and aerospace applications as well as in monitoring systems for highly critical structures such as dikes and bridges. &nbsp;Another exciting area is NIR spectral sensing modules and components for analysis of fruit and vegetable nutrients, taste, and structure insights, which will meet increasing global concerns about food safety, storage, and traceability. Selected Integrated Photonics applications will be addressed in future articles.<h2 data-element-id="headingsMap-13-0">Conclusion</h2>Integrated Photonics is a rapidly emerging technology and industry which offers a dramatic reduction of costs and size for many communications and sensing components. As such offering huge potential to enable disruptive innovative products and solutions across industries and applications. Integrated Photonics is growing rapidly into one of the defining technologies of our time. &nbsp;<hr><h2 data-element-id="headingsMap-14-0">About the sponsor: PhotonDelta</h2><a href="https://www.photondelta.com/" rel="noopener noreferrer" target="_blank" id="isPasted">PhotonDelta&nbsp;</a> is a growth accelerator for the Dutch integrated photonics industry. Its objective is to promote the adoption of integrated photonics and support companies to get prioritized access to the Dutch Integrated Photonics supply chain. Furthermore, PhotonDelta runs a new business creation program that provides companies, ranging from startups to SMEs and big organizations, with access to strategy, market, and funds.Through its wide network within the industry, PhotonDelta has gathered insights on market trends, challenges, and product roadmaps. This information is used to drive business creation, investments, and strategic technology roadmaps. Furthermore, PhotonDelta actively supports start-ups and SMEs to facilitate their involvement with the Dutch integrated photonic supply chain. This includes facilitating options for establishing a solid presence in the Netherlands.<h1><img class="fr-fic fr-dib" src="https://images.wevolver.com/eyJidWNrZXQiOiAid2V2b2x2ZXItcHJvamVjdC1pbWFnZXMiLCAia2V5IjogImZyb2FsYS8xNjA2MjAzNDcwNjM2LXBob3RvbiBkZWx0YSBhcnRpY2xlIGJvdHRvbSBiYW5uZXIuanBnIiwgImVkaXRzIjogeyJyZXNpemUiOiB7IndpZHRoIjogOTUwLCAiZml0IjogImNvdmVyIn19fQ==" style="width: 788px;"></h1><h2 data-element-id="headingsMap-16-0">References</h2><ol start="1" type="1"><li><a href="https://www.photonics.com/Articles/Integrated_Photonics_Looks_to_Advance_Safety_for/a64791" target="_blank" id="isPasted">https://www.photonics.com/Articles/Integrated_Photonics_Looks_to_Advance_Safety_for/a64791</a></li></ol><ol start="2" type="1"><li>ERICSSON Mobility Report November 2017, Mobile data traffic growth outlook. [Online] Available at: https://www.ericsson.com/en/ mobility-report/reports/november2017/mobile-data-traffic-growth-outlook</li></ol>

Article 2 of our Integrated Photonics series: Integrated Photonics is enabling innovation in a broad and expanding list of applications.

Key Application Areas for Integrated Photonics

Motion capture and the field of motion measurement are widely used in both sports and creative visual media. But in this recent short film, ‘<a href="https://vimeo.com/453613568" rel="noopener" target="_blank">Protesys</a>’ by acclaimed Brazilian director, Afonso Poyart, the worlds of sport science and Hollywood collide, and <a href="https://www.xsens.com/products/mvn-animate" rel="noopener" target="_blank">Xsens MVN Animate</a> is at the center of production.&nbsp;Afonso’s filmmaking career has earned him a highly regarded place in the global film industry, directing films such as Two Rabbits&nbsp;(2012), Solace (2015), and Mais Forte que o Mundo: A História de José Aldo (2016), to name a few. In Protesys, conventional wisdom surrounding sports is challenged head-on, tackling the increasing role technology plays in professional sports. In particular, the film – shot convincingly as a fictional documentary – focuses on the potential for high-powered, bionic prosthetics that take a step beyond assistance for para-athletes, elevating users to superhuman levels of performance. Afonso partnered with VFX studio, <a href="https://www.picmapost.com.br/" target="_blank">Picma Post</a>, to design the short film’s photorealistic visuals, creating a convincing and realistic technology concept, all despite being set in an entirely fictional context.&nbsp;We spoke with Afonso Poyart and Rodrigo Elias, founding partner and production supervisor at Picma Post, about the film’s inception, production, and the studio’s future projects.&nbsp;<iframe allowfullscreen="" class="fr-draggable" frameborder="0" src="https://www.youtube.com/embed/b6vjCVq4UQo?&amp;feature=emb_logo&amp;wmode=opaque" style="width: 784px; height: 503px;"></iframe> Perceiving Protesys&nbsp;Afonso was inspired by the incredible feats achieved by today’s para-athletes on the world stage, taking a keen interest in the role of advancements in prosthetic limbs. As prosthetic technology continues to improve, para-athletes are beginning to edge closer to the level of able-bodied sports stars, which begs the question: could robotic technology turn the tables?&nbsp;“We’ve started to see current-day parathletes, with the help of modern prosthetics, beginning to enter into higher and higher levels of sporting achievement, this inspired the basis of the film idea,” said Afonso.&nbsp;“What would happen if they equalled, and then bettered able-bodied athletes?” continued Afonso.&nbsp;With this concept in mind, Afonso opted to sculpt a world containing a new bionic prosthetic that while beyond today’s capabilities, feels like an entirely possible adaptation. You’d be forgiven for taking the premise of the film as fact, especially as it’s presented in a documentary form that demonstrates the technology as market-ready. It even stars an active, Brazilian para-athlete, Flavio Reitz:&nbsp;“Flavio is a real para-athlete from the Olympics – it’s like real life meets fiction. In the story, this futuristic tech company hires Flavio to test the new equipment,” explained Afonso.The bionic technology developed by the company goes far beyond normal expectations. Rather than just replacing the limb with something inactive, the new bionic prosthetic enhances the user’s physical ability to superhuman levels and is controlled like a regular limb using a computer chip implanted in the brain. Elon Musk’s Neuralink technology played some part in the inspiration for the brain implant idea.&nbsp;“Neuralink definitely provided some inspiration for the chip that connects the motor cortex in the brain with the robotic limbs. However, I didn’t want to fool people too much or give false hope – we wanted to create something that plays with the audience but becomes clearer as the film plays out. It’s too high-tech for today,” said Afonso.&nbsp;&nbsp;<img alt="20191020_153232-1" class="fr-fic fr-dii" sizes="(max-width: 600px) 100vw, 600px" src="https://images.wevolver.com/eyJidWNrZXQiOiAid2V2b2x2ZXItcHJvamVjdC1pbWFnZXMiLCAia2V5IjogImZyb2FsYS8xNjA0NjU5NDc5NTUwLTE2MDQ2NTk0Nzk1NTAucG5nIiwgImVkaXRzIjogeyJyZXNpemUiOiB7IndpZHRoIjogOTUwLCAiZml0IjogImNvdmVyIn19fQ==" width="600">Production ProcessThrough its high production standard, the short film manages to blur the line between fiction and reality, particularly in the CG animated sections that show off the prosthetic technology. To achieve this, the VFX studio utilized motion capture to generate realistic movements of athletes performing a range of sports.&nbsp;“When we first started discussing the idea and concept for the short film, we realized we needed an accurate mocap suit to record athletic movements. Here in Brazil, we don’t have lots of mocap studios or specialists, but our research led us to <a href="https://www.xsens.com/" rel="noopener" target="_blank">Xsens</a> as the best solution. We talked a lot with the Xsens team when setting up to get the highest quality data,” explained Rodrigo.&nbsp;With a short time frame to learn how to use Xsens, the team found the technology’s ease-of-use and adaptability invaluable to the production process.&nbsp;“It was a really straightforward process for us. Picma had never operated a full mocap system and it was a learning process from scratch. Despite this, we were able to pick it up quickly,” said Afonso.&nbsp;“We were able to complete a lot of mocap directly on an athletics track. Nobody has capabilities like Xsens to complete sessions such as this,” continued Afonso.&nbsp;With the ability to record athletes live on the track, the <a href="https://www.picmapost.com.br/" rel="noopener" target="_blank">Picma Post</a> team could record the full-body motion of boxers, dancers, and high jumpers with ease, generating the realistic, CG animation seen throughout the film. Picma used several stunt doubles for Flavio's routines, harmoniously merging the shots together.&nbsp;“Flavio is unable to use a real prosthetic leg and can’t walk. So every shot where he is walking is a double. We also hired a High Jumper for some of the shots too,” said Afonso.&nbsp;“We actually had three stuntmen for Flavio, one for jumping, running, and the body! added Rodrigo. “But of course, we only recorded the initial steps of Flavio’s jump with <a href="https://www.xsens.com/" rel="noopener" target="_blank">Xsens</a>. We also had some wired cables that raised him during the recording session. As soon as he took off and went upwards, we’d cut, so the rest of the jump was all CG.”&nbsp;<img alt="IMG_0906.CR2" class="fr-fic fr-dii" sizes="(max-width: 1200px) 100vw, 1200px" src="https://images.wevolver.com/eyJidWNrZXQiOiAid2V2b2x2ZXItcHJvamVjdC1pbWFnZXMiLCAia2V5IjogImZyb2FsYS8xNjA0NjU5NDc5MTE2LTE2MDQ2NTk0NzkxMTYucG5nIiwgImVkaXRzIjogeyJyZXNpemUiOiB7IndpZHRoIjogOTUwLCAiZml0IjogImNvdmVyIn19fQ==" width="1200">“For the CG parts, we used a combination of Maya and Arnold. And every compositing shot is completed in Nuke. For now, we’re using HumanIK inside Maya to apply the mocap data and a custom rig using HumanIK as our base for the robot. We’re looking to develop custom rigs in the future,” said Rodrigo. Even high-impact movements resulted in no loss of data for the team, with the durability of the Xsens sensors proving very reliable. “We recorded a high jumper with Xsens to jump at a lower height to acquire all of the movement data as an athlete crosses over the bar. The data came out very clean, all despite the athletes hitting the mattresses with maximum force – the sensors worked fine,” explained Afonso.<iframe allowfullscreen="" allowtransparency="true" frameborder="0" height="100%" scrolling="no" src="https://play.vidyard.com/7RvtWS9otmd6jKYHf2Gx81?disable_popouts=1&amp;type=inline&amp;hidden_controls=0&amp;muted=0&amp;loop=0&amp;autoplay=0&amp;new_player_ui=1&amp;gdpr_enabled=1&amp;play_button_color=2A2A2A&amp;playlist_color=FFFFFF&amp;color=FFFFFF&amp;hide_playlist=1&amp;embed_button=0&amp;viral_sharing=0&amp;v=4.2.23&amp;vydata%5Butk%5D=e1b95d4c524d7134054b8a9c5fc2f599&amp;vydata%5Bportal_id%5D=3446270&amp;vydata%5Bcontent_type%5D=blog-post&amp;vydata%5Bcanonical_url%5D=https%3A%2F%2Fwww.xsens.com%2Fcases%2Fdesigning-a-bionic-future-for-prosthetics-with-xsens&amp;vydata%5Bpage_id%5D=35219307837&amp;vydata%5Bcontent_page_id%5D=35219307837&amp;vydata%5Blegacy_page_id%5D=35219307837&amp;vydata%5Bcontent_folder_id%5D=null&amp;vydata%5Bcontent_group_id%5D=9880291723&amp;vydata%5Bab_test_id%5D=null&amp;vydata%5Blanguage_code%5D=null" title="Video" width="100%"></iframe>Feature FilmThe short is a stand-alone film in its own right, but it actually exists within a much larger universe designed by Afonso to encompass a feature-length, parallel story.&nbsp;“The short film is a case study for a feature film in production. We have a script and are just entering the production stages – the short film takes place in the same universe as the feature and acts as a precursor,” said Afonso.&nbsp;“The movie portrays a world where prosthetics are incredibly advanced. We’ve focused on different athletic sports where para-athletes use bionic limbs to become super athletes. The sporting audience and sponsors flip their interest into the bionic sports, able-bodied athletes become less significant as they’re unable to compete with para-athletes,” continued Afonso.&nbsp;“There will be two sisters, both athletes, one disabled and one able-bodied. When this technological revolution happens, the sister with the disability becomes the star, replacing the prospects of the able-bodied sister. It’s really about rivalry and what people are prepared to do to achieve success.”The feature film will take a more conventional cinematic approach, rather than the fictional documentary style of the short. But the questions touched upon in <a href="https://vimeo.com/453613568" rel="noopener" target="_blank">Protesys</a> will be expanded into realistic scenarios that are bound to cause contention. As Afonso states:&nbsp;“We always associate sports with physicality, but it seems to me that it’s much more about mental and emotional dexterity. If the robotics extends our physical ability to a higher level and really lowers difficulty constraints, what will differentiate the best athletes? Everyone might want a bionic limb, whether they need one or not.” You can check out the full short film <a href="https://www.solidlimbs.com/" target="_blank">here</a>, and keep your eyes peeled for further developments of the full feature film.&nbsp;&nbsp;<h3>Xsens MVN Animate</h3>Are you actively looking for a motion capture system? Feel free to visit our&nbsp;<a href="https://www.xsens.com/products/mvn-animate" rel="noopener noreferrer" target="_blank">product page</a>.<a href="https://www.xsens.com/cs/c/?cta_guid=62b0c95c-a32e-49a7-b027-2d1850d6c247&amp;signature=AAH58kHW8MGtxYkdRDy65TvwW8WxSoQlgA&amp;pageId=35219307837&amp;placement_guid=4d5a34f5-b6e3-4815-bb7c-67fec396482b&amp;click=d23fe1e1-9172-412a-af80-683795572401&amp;hsutk=e1b95d4c524d7134054b8a9c5fc2f599&amp;canon=https%3A%2F%2Fwww.xsens.com%2Fcases%2Fdesigning-a-bionic-future-for-prosthetics-with-xsens&amp;utm_referrer=https%3A%2F%2Fwww.xsens.com%2Fexplore%3Ffilter%3Dcases&amp;portal_id=3446270&amp;redirect_url=APefjpGczQu9wTNyNGmpb35KO0ZULXNHCqF9PkcH0Ho_6IWdyVwW2gu7s3VrxVumJdj3ZRgAd-220-M-7t0z5K_7GUyeMXeatlgMTlmpeIGz2ZoeriA-BJaRg2VrfHuyZEc8af2uCoVe4z_uyouYcGJWjoCuaaJ09pUhGzenbaRrw0IdC_wGbSbd4yyuUJ3xAopxB3HeKGgBp1JutLsNSkMy98evDLdzARZUnyn6TyX5GjiVzaODc8xdJtRc3xVBgNdq7JJUUPhXoG5xPx_AvClAVrZAzelHPw&amp;__hstc=81749512.e1b95d4c524d7134054b8a9c5fc2f599.1598950583555.1604655289703.1604659070195.177&amp;__hssc=81749512.5.1604659070195&amp;__hsfp=141168424&amp;contentType=blog-post" target="_blank" title="Download MVN Data Files"></a>

With Xsens

Designing A Bionic Future For Prosthetics

<a href="https://www.openbionics.com/" target="_blank">Open Bionics</a> is creating the next generation of prosthetic limbs. What sets these apart from traditional prosthetics is that all of the mechanical parts are 3D printed, bringing along considerable cost-savings. The models created by Open Bionics are both functional and aesthetically pleasing, making sure its wearer feels comfortable wearing them - both physically and socially.&nbsp;<iframe src="https://www.youtube.com/embed/ipP-z_koTZs?&amp;wmode=opaque" frameborder="0" allowfullscreen="" class="fr-draggable" style="width: 789px; height: 456px;"></iframe>Bionic hands can be very expensive. Starting at about $35,000, they can go up to even $120,000. Open Bionics is developing a bionic hand that offers the same functionality at under $1,200.<h2>The 3D printed prosthetic</h2>The Open Bionics hand is suited for trans-radial amputees: people that still have an elbow joint but miss anywhere from their hand upwards. The prosthetic works through sensors that are placed on the wearer's muscles. These send out an electric signal that allows the hand to move when specific muscles are flexed. Each finger can be moved independently and with varying speed, allowing for different gripping modes and movements to be made.<img src="https://s3-us-west-1.amazonaws.com/wevolver-project-images/froala%2F1602664181040-Bionic_hand_sensor_placement.webp">Sensors are placed on the wearer's muscles&nbsp;<img src="https://s3-us-west-1.amazonaws.com/wevolver-project-images/froala%2F1602664198362-Open_Bionics_hand_movement.webp">Muscle movements allow the hand to move in various ways&nbsp;<section>3D printing plays a vital part in the development of the Open Bionics hand. After 3D scanning the wearer's residual limb, a prosthetic design is made in 3D modeling software, after which both the hand and its socket are 3D printed.As all the mechanical components of the hand can be 3D printed, it becomes a cost-effective alternative to the traditional, expensive prosthetic. As it's about 30 times cheaper than other available alternatives, it helps to make robotic hands accessible to a wider audience.<h2>Rigid and flexible materials</h2>The Open Bionics hands are created using both rigid and flexible materials to support the varying functionalities of different parts of the hand. The fingers are printed in one piece with <a href="https://ultimaker.com/materials/tpu-95a" target="_blank">flexible TPU</a> and have joints built-in that work directly after the printing has finished. Other parts, that need to be more rigid, are printed with <a href="https://ultimaker.com/materials/pla" target="_blank">PLA</a>. Since the fingers' joints are built-in, the number of different parts that need to be manufactured is greatly reduced, which simplifies the assembly process.<img src="https://s3-us-west-1.amazonaws.com/wevolver-project-images/froala%2F1602664225372-3D_printing_prosthetic_hand.webp">Different materials are used for different parts of the hand&nbsp;<img src="https://s3-us-west-1.amazonaws.com/wevolver-project-images/froala%2F1602664249526-Flexible_prosthetic_finger_joints+%281%29.webp"><figure type="ArticleImage"><figcaption>The soft fingers are printed in one piece with flexible material</figcaption></figure>3D printing not only shrinks the development costs of these bionic hands - it also allows for tailor-made designs to be implemented that perfectly match the wearer's wants and needs. Check the <a href="https://www.openbionics.com/" target="_blank">Open Bionics website</a> to stay up-to-date on the progress made in this field.As this case illustrates, 3D printing can radically change the way in which medical applications are approached. For an overview of other 3D printing applications in the medical field, check out our explore pages: <a href="https://ultimaker.com/en/explore/where-is-3d-printing-used/medicine" rel="noopener noreferrer" target="_blank">https://ultimaker.com/en/explore/where-is-3d-printing-used/medicine</a><hr>Disclaimer:&nbsp;Ultimaker 3D printers are designed and built for Fused Filament Fabrication with Ultimaker engineering thermoplastics within a commercial/business environment. The mixture of precision and speed makes the Ultimaker 3D printers the perfect machine for concept models, functional prototypes and the production of small series. Although we achieved a very high standard in the reproduction of 3D models with the usage of Ultimaker Cura, the user remains responsible to qualify and validate the application of the printed object for its intended use, especially critical for applications in strictly regulated areas like medical devices and aeronautics.</section>

Open Bionics is creating the next generation of prosthetic limbs. What sets these apart from traditional prosthetics is that all of the mechanical parts are 3D printed, bringing along considerable cost-savings.

Open Bionics: 3D printed prosthetic limbs

With the increased accessibility and democratization of technologies that allow for rapid design iteration and customization, such as 3D printing, more and more innovative groups are taking the initiative to reevaluate how the use of this technology can improve upon existing systems. One of these groups is DiveDesign, who is working to use 3D printing to optimize the process of creating custom full limb pet prosthetics. In this article, we share their story: from the partnerships they&rsquo;ve created, through the research and development that went into their new process, to the lives they&rsquo;ve changed along the way.&nbsp;<h2 dir="ltr">Identifying An Opportunity&nbsp;</h2><a href="https://www.divedesignco.com/" target="_blank">DiveDesign</a> is the creation of Adam Hecht and Alex Tholl, who started their product development studio while still in college. While they mainly offer their services such as design research and strategy, concept development, prototyping, engineering, and brand development, their shared interest in technology has expanded their business and outlook towards finding opportunities for leveraging technology to improve upon existing systems used to design products.The team discovered one of these opportunities through their introduction to Derrick Campana of <a href="https://bionicpets.org/" target="_blank">Bionic Pets</a>, a leading provider of animal orthotics and prosthetics. Campana has been creating animal orthotic and prosthetic devices since 2005, and has provided custom braces and prosthetics for thousands of animals throughout his career. From speaking with Campana, Hecht and Tholl learned of the frustrations involved with the current process of creating full limb prosthetic devices for dogs, which had the ability to become a large portion of Bionic Pet&rsquo;s business.&nbsp;Traditionally, to create a full limb prosthetic (when the dog is missing an entire front leg), a negative mold is created of the patient using 3M ACE style bandages that is hardened using Plaster of Paris. Then, plastic sheets are heated and bent around the negative mold. Afterwards, it is trimmed and finished, and the foam and leg hardware components are attached.<img src="https://s3-us-west-1.amazonaws.com/wevolver-project-images/froala%2F1589852049169-unnamed+%286%29.png">Traditional method of creating the full limb prosthetics&nbsp; Although Campana has refined the process of creating full limb prosthetics, there were still many areas for improvement. While creating a brace takes little less than 2 hours, the process of creating a full limb prosthetic can usually take up to 15-20 (depending on the size of the prosthetic), and oftentimes does not account for adjustments after test fitting.Hecht and Tholl realized that there was an opportunity to improve upon this process. Leaning on their experience with 3D printing and scanning, they partnered with Campana to create a new method for creating full limb pet prosthetics.&nbsp;<h2 dir="ltr">Designing A New Process</h2>Hecht and Tholl began with the idea that by 3D scanning the negative mold and using the scan to create a 3D-printable customized prosthetic model, the need for heating, bending and finishing the plastic sheets would be eliminated, saving hours of manual labor.In addition to saved time, there were other advantages to this new approach: by incorporating digital tools into the process, it was now easier to modify the prosthetic after test fitting if needed. Through 3D printing the prosthetic, there would be more options for materiality, which would allow the prosthetic to be optimized for comfort, breathability, and flexibility.&nbsp;Another goal for the new process was to allow the workload to be distributed within a team, which was not an option with the existing process. &ldquo;For example,&rdquo; Tholl explained, &ldquo;(in the past) if Derrick was too busy one week, no body jackets got made because he&rsquo;s the only one who can make them. With the new process, we wanted to be able to train a team to support the process.&rdquo;&nbsp;With this in mind, the team began testing their new approach. They started by 3D scanning the Plaster of Paris molds and manipulating the scans with preexisting CAD tools. It was after preparing multiple prosthetic models for printing with these tools that they realized the extensive amount of manual digital labor that it required. &ldquo;We knew that creating a digital tool to perform the same actions with minimal user input was the key to a sustainable model.&rdquo; stated Hecht.<img src="https://s3-us-west-1.amazonaws.com/wevolver-project-images/froala%2F1589852032851-pasted+image+0+%281%29.png">3D scanning a negative mold&nbsp; <img src="https://s3-us-west-1.amazonaws.com/wevolver-project-images/froala%2F1589852146357-pasted+image+0+%282%29.png">Development of the new algorithm&nbsp;This realization led them to partnering with Chris Landau of <a href="https://www.landau.design/" target="_blank">Landau Design + Technology&nbsp;</a>to create an algorithm specifically for generating prosthetic models from 3D scans to aid them in their process. Through this algorithm, it was possible to generate finalized 3D printable models of the prosthetics in a fraction of the time. It also allowed for further customization of each prosthetic through changing mount positions, thicknesses, and more.<h2 dir="ltr">Research &amp; Development</h2>With considerations towards cost, processing and printing time, and comfort, Hecht and Tholl designed and printed countless iterations of the prosthetics and worked with Landau to fine-tune the features of the algorithm. &ldquo;To be honest, the first design was us making sure we could even print something that could fit a large dog and be comfortable. Derrick at Bionic Pets sat with us for many hours going over the importances of support placement, sizing, flexibility, strength.&rdquo; Tholl recalled. &ldquo;Not only did we want the new design to be faster to make, we also wanted it to be a better product for the dog.&rdquo; Hecht added.The largest challenge throughout development came with finding a material to print the prosthetics with. &ldquo;We tried at least 10 different materials before landing on TPU,&rdquo; Tholl stated. TPU, or thermoplastic polyurethane, is a plastic known for its elasticity and high abrasion resistance. &ldquo;With this material we found the perfect combination of flex for comfort, and strength for support. It also enabled us to print a heavily ventilated pattern that enabled more breathability, unlike other materials that would have required being printed solid.&rdquo;&nbsp;<img src="https://s3-us-west-1.amazonaws.com/wevolver-project-images/froala%2F1589852191030-pasted+image+0+%283%29.png">Prosthetic 3D printed with TPU &nbsp;Other characteristics of TPU that made it a good choice for printing the prosthetics were its microbial resistance, water resistance, and ability to be applied on or near the skin, which were important considerations when planning for the prolonged attachment to the patient.&nbsp;As with any thorough design development, it was important to validate that the product would function as intended for the end user, and meet all the necessary comfort and safety requirements. However, this user validation was unlike any DiveDesign had tackled in the past. &ldquo;It was tough because we had so many criteria to meet that would allow Derrick to approve our methods. Most importantly, we wanted to make sure that the fit was right. We were also looking to ensure that it moved with the dog and did not restrict them, was breathable and wouldn&rsquo;t cause discomfort, and it could withstand the expected wear and tear.&rdquo; explained Tholl.Fortunately, there were pet families who were willing to participate in the initial testing under Campana&rsquo;s supervision. This allowed DiveDesign to be confident that the prosthetics they were sending out to future patients were up to Campana&rsquo;s standards.&nbsp;One of these families were the owners of a dog named Hope, who volunteered to test one of the finalized prosthetics made through the new process. &ldquo;Hope&rsquo;s family really helped us to make sure what we were creating functioned in the way that it needed to, and Derrick was present digitally to watch and make sure his standards were being exceeded.&rdquo; Hecht explained.&nbsp;<img src="https://s3-us-west-1.amazonaws.com/wevolver-project-images/froala%2F1589852229109-pasted+image+0+%284%29.png">Test fitting Hope&rsquo;s full limb prostheticThrough families like Hope&rsquo;s, the team was able to conduct invaluable testing that allowed them to confirm that their process produced a viable alternative to traditional prosthetics, as well as better understand the unique challenges that came with every patient.<h2 dir="ltr">Creating The Prosthetics</h2><img src="https://s3-us-west-1.amazonaws.com/wevolver-project-images/froala%2F1589852304525-pasted+image+0+%285%29.png">Preparing prosthetics for shipment&nbsp;Once the process had been tested and verified,the recurring orders for full limb prosthetics that Bionic Pets was receiving could be fulfilled using the new 3D printing-centric process. To date, the team has completed over 30 orders for prosthetics, with more coming in every day. As they are fine-tuning the process, the partnership between DiveDesign, Campana, and Landau has remained crucial. The prosthetics are being closely monitored by Campana, and the algorithm is continuing to be developed under the guidance of Landau.<img src="https://s3-us-west-1.amazonaws.com/wevolver-project-images/froala%2F1589852731963-1241243123123.png">Fully assembled prosthetics &nbsp;While this endeavour has been a large undertaking for the team, the joy of seeing their prosthetics being used to change the lives of pets and their families has made it well worth it. &ldquo;Seeing (the pets&rsquo;) progress as they learn to move with the prosthetic..seeing them run for the first time, it&rsquo;s great to see.&rdquo; Hecht said. &ldquo;It&rsquo;s like an indescribable feeling. Never in a million years did we ever think we&rsquo;d be developing animal prosthetics using 3D printing.&rdquo; Tholl added.<img src="https://s3-us-west-1.amazonaws.com/wevolver-project-images/froala%2F1589852759499-12565474.png" style="width: 788px;" class="fr-fic fr-dib"><h2 dir="ltr">Looking To The Future</h2>As production of the prosthetics continues, the team is keeping their mind on expanding their operations. With the assistance of 3D printing service centers such as <a href="https://www.gcreate.com/" target="_blank">gCreate</a> in Brooklyn, NY, they are working to keep up with the large influx of orders they are receiving each month.&nbsp;For Hecht and Tholl, this project has inspired them to continue finding ways to use the technology they have available to them to solve problems and help others. &ldquo;We are excited to see where we will go from here, and what further applications for 3D printing we will find in the future.&rdquo; said Tholl.&nbsp;You can learn more about this project through<a href="https://www.divedesignco.com/work/bionic-pets" target="_blank">&nbsp;DiveDesign&rsquo;s</a> website, and by following <a href="https://www.instagram.com/divedesignco/?hl=en" target="_blank">DiveDesign</a> and <a href="https://www.instagram.com/bionicpets/?hl=en" target="_blank">Bionic Pets</a> on Instagram. You can also learn more about the story of two of their patients, Turbo Roo &amp; Thor, on Campana&rsquo;s new show <a href="https://www.byutv.org/player/8d089869-c4d2-40f2-a7b2-e718a216952e/wizard-of-paws-turbo-roo-thor" target="_blank">The Wizard of Paws</a> on BYUtv.&nbsp;<hr>References:<ul style="list-style-type: circle;"><li><a href="https://www.divedesignco.com/" target="_blank">https://www.divedesignco.com/</a></li><li><a href="https://bionicpets.org/" target="_blank">https://bionicpets.org/</a></li><li><a href="https://www.landau.design/" target="_blank">https://www.landau.design/</a></li><li><a href="https://www.byutv.org/player/8d089869-c4d2-40f2-a7b2-e718a216952e/wizard-of-paws-turbo-roo-thor" target="_blank">https://www.byutv.org/player/8d089869-c4d2-40f2-a7b2-e718a216952e/wizard-of-paws-turbo-roo-thor</a></li></ul>

A New Jersey-based product development studio has paired with an algorithm developer and one of the nation’s leading animal orthotists to optimize the process of creating full-limb pet prosthetics.

Utilizing 3D Printing To Create Pet Prosthetics

The human heart beats approximately 35 million times every year, pumping blood via four different heart valves. Unfortunately, &nbsp;in more four million people each year, these delicate tissues malfunction due to birth defects, age-related deteriorations, and infections causing cardiac valve disease.Today, clinicians use either artificial prostheses or fixed animal and cadaver-sourced tissues to replace defective valves. While these prostheses can restore the function of the heart for a while, they are associated with adverse comorbidity and wear down and need to be replaced during invasive and expensive surgeries. Moreover, in children, implanted heart valve prostheses need to be replaced even more often as they cannot grow with the child.A team lead by&nbsp;<a href="https://www.seas.harvard.edu/directory/kkparker" target="_blank">Kevin Kit Parker</a>, Tarr Family Professor of Bioengineering and Applied Physics at the<a href="http://www.seas.harvard.edu/" target="_blank">&nbsp;Harvard John A. Paulson School of Engineering and Applied Sciences&nbsp;</a>(SEAS), recently developed a nanofiber fabrication technique to rapidly manufacture heart valves with regenerative and growth potential.Parker is also a Core Faculty member of&nbsp;<a href="http://wyss.harvard.edu/" target="_blank">Wyss Institute for Biologically Inspired Engineering at Harvard University.</a>In a paper published in&nbsp;<a href="http://www.sciencedirect.com/science/article/pii/S0142961217302685" target="_blank">Biomaterials</a>, first author Andrew Capulli and colleagues fabricated a valve-shaped nanofiber network that mimics the mechanical and chemical properties of the native valve extracellular matrix (ECM). The team used the Parker lab&rsquo;s proprietary rotary jet spinning technology &ndash; in which a rotating nozzle extrudes an ECM solution into nanofibers that wrap themselves around heart valve-shaped mandrels.&ldquo;Our setup is like a very fast cotton candy machine that can spin a range of synthetic and natural occurring materials,&rdquo; said Parker. &ldquo;In this study, we used a combination of synthetic polymers and ECM proteins to fabricate biocompatible JetValves that are hemodynamically competent upon implantation and support cell migration and re-population&nbsp;in vitro. Importantly, we can make human-sized JetValves in minutes &ndash; much faster than possible for other regenerative prostheses.&rdquo;To further develop and test the clinical potential of JetValves, Parker&rsquo;s team partnered with the translational team of Simon P. Hoerstrup, at the University of Zurich. As a leader in regenerative heart prostheses, Hoerstrup and his team in Zurich previously developed regenerative, tissue-engineered heart valves to replace mechanical and fixed-tissue heart valves. In Hoerstrup&rsquo;s approach, human cells directly deposit a regenerative layer of complex ECM on biodegradable scaffolds shaped as heart valves and vessels. The living cells are then eliminated from the scaffolds resulting in an &ldquo;off-the-shelf&rdquo; human matrix-based prostheses ready for implantation.In the paper, the cross-disciplinary team successfully implanted JetValves in sheep using a minimally invasive technique and demonstrated that the valves functioned properly in the circulation and regenerated new tissue.&ldquo;In our previous studies, the cell-derived ECM-coated scaffolds could recruit cells from the receiving animal&rsquo;s heart and support cell proliferation, matrix remodeling, tissue regeneration, and even animal growth. While these valves are safe and effective, their manufacturing remains complex and expensive as human cells must be cultured for a long time under heavily regulated conditions. The JetValve&rsquo;s much faster manufacturing process can be a game-changer in this respect. If we can replicate these results in humans, this technology could have invaluable benefits in minimizing the number of pediatric re-operations,&rdquo; said Hoerstrup.

In rotary jet spinning technology, a rotating nozzle extrudes a solution of extracellular matrix (ECM) into nanofibers that wrap themselves around heart valve-shaped mandrels. By using a series of mandrels with different sizes, the manufacturing process becomes fully scalable and is able to provide JetValves for all age groups and heart sizes. (Photo courtesy of Wyss Institute at Harvard University)

Harvard and the University of Zurich partner to create a next-generation heart valve that accurately functions upon implantation and regenerates into long-lasting heart-like tissue

Engineering heart valves for the many

<a href="http://eas.caltech.edu/people/mgharib" target="_blank">Mory Gharib</a> (PhD &#39;83), the Hans W. Liepmann Professor of Aeronautics and Bioinspired Engineering in the Division of Engineering and Applied Science, and postdoctoral researcher Chris Roh (MS &#39;13, PhD &#39;17) studied Anisopteran dragonfly larvae, which live in water and both breathe and move by inhaling water, extracting oxygen from it, and then expelling the water back out through a tri-leaflet anal valve that is surprisingly similar in structure to tricuspid human heart valves.&nbsp;The larvae are able to control the retraction of each of the three leaves individually, and this, Gharib and Roh discovered, gives them fine control over the size and symmetry (or asymmetry) of the valve opening.&nbsp;&quot;The dragonfly larva is the only insect that uses jet propulsion to move and the only arthropod known to use reciprocal jetting&mdash;inhaling and exhaling through the same orifice&mdash;for underwater breathing,&quot; says Roh, the lead author of a paper on the larval jets that was published online by the journal Bioinspiration &amp; Biomimeticson May 30.&nbsp;To observe how the larvae directed the flow of water using the leaves on their anal valves, Gharib and Roh set up high-speed cameras around an aquarium filled with a colored dye and tethered 96 dragonfly larvae&mdash;one at a time&mdash;in front of the cameras using dental wax. They found that when the larvae retracted all three leaves, the water jet flows straight out, pushing the animals straight forward. Retracting just one or two leaves, on the other hand, results in an asymmetric flow, which the larvae use when breathing.&quot;The way the dragonfly larvae use their unique adaptation to control the jet direction has previously been overlooked,&quot; says Gharib, senior author of the paper. &quot;The asymmetry control by the larvae is an intriguing jet-vectoring mechanism, different from those of squids or salps that simply point their funnels or siphons in a desired direction.&quot;Like the anus of the dragonfly larvae, heart valves have two or three leaves (depending on the valve) that control the flow. Gharib and Roh intend to use what they have learned from the dragonflies to engineer a new prosthetic multi-leaf heart valve that can direct jets in specific directions that mimic natural blood flow emerging from the valve, which is never perfectly symmetric. Currently, the unnaturally symmetrical flow of blood emerging from prosthetic valves can cause blood clots to form or even be abrasive to the walls of blood vessels. To cope with this unintended side effect of prosthetic heart valves, patients typically must spend the rest of their lives taking blood-thinning medications.&nbsp;&quot;The current heart valve design is a one-size-fits-all, where no patient-specific design is considered, and this causes many post-transplant complications,&quot; Roh says. &quot;We believe that an intentionally off-centered opening of the heart valve to more closely match the patient&#39;s original blood flow will be an important design parameter that can be adjusted based on each patient&#39;s heart morphology.&quot;

Seen as a light-colored plume, water jets out from the back of a larval dragonfly. Credit: Chris Roh and Mory Gharib/Caltech

A new understanding of the mechanics of dragonfly larvae respiration and maneuvering could lead to the next generation of prosthetic heart valves, say Caltech engineers.

Dragonfly Larvae Inspire New Designs for Prosthetic Heart Valves

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