New granular hydrogel bioink could expand possibilities for tissue bioprinting

Penn State researchers have developed a novel nanoengineered granular hydrogel bioink that makes use of self-assembling nanoparticles and hydrogel microparticles, or microgels, to achieve previously unattained levels of porosity, shape fidelity and cell integration.

05 Sep, 2022

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Penn State researchers developed a new nanoengineered granular hydrogel bioink, used here to print an image of the Nittany Lion logo. This bioink helps to achieve previously unattained levels of porosity, shape fidelity and cell integration when 3D printing biomaterials. Credit: Provided by Amir Sheikhi. All Rights Reserved.

Penn State researchers developed a new nanoengineered granular hydrogel bioink, used here to print an image of the Nittany Lion logo. This bioink helps to achieve previously unattained levels of porosity, shape fidelity and cell integration when 3D printing biomaterials. Credit: Provided by Amir Sheikhi. All Rights Reserved.

Every day in the United States, 17 people die waiting for an organ transplant, and every nine minutes, another person is added to the transplant waiting list, according to the Health Resources and Services Administration. One potential solution to alleviate the shortage is to develop biomaterials that can be three-dimensionally (3D) printed as complex organ shapes, capable of hosting cells and forming tissues. Attempts so far, though, have fallen short, with the so-called bulk hydrogel bioinks failing to integrate into the body properly and support cells in thick tissue constructs. 

Now, Penn State researchers have developed a novel nanoengineered granular hydrogel bioink that makes use of self-assembling nanoparticles and hydrogel microparticles, or microgels, to achieve previously unattained levels of porosity, shape fidelity and cell integration.

The team published their approach in the journal Small. Their work will be featured on the journal’s cover.

05 Sep, 2022

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